Injection should be given in any one spot more often than every two weeks. Site rotation is important to prevent or combat which of the following complications?

C Formation of glucagon promotes a rise in blood sugar, thereby, producing hyperglycemia. B Rapid absorption of insulin due to tissue sensitivity. A Abnormal tissue changes which may result in poor absorption of the injected insulin. D Increased blood glucocorticoids raise blood sugar by stimulating the conversion of fat and protein into glucose.