Difficulty: Medium
Average Score: 66%
Simulated
Which statement indicates a correct understanding of topical drug absorption in a pediatric patient?
Correct answer
D
Rationale
Correct Answer: D
Rationale: Infants wearing plastic-coated diapers are more susceptible to skin absorption due to occlusion by the diaper, leading to increased permeability of the skin and enhanced drug absorption. Plastic-coated diapers create a warm and moist environment that increases skin hydration, facilitating drug penetration. This is important for topical drug absorption in pediatric patients.
Summary:
A: Incorrect. Skin hydration does not solely determine the absorption of water-soluble drugs in pediatric patients.
B: Incorrect. Inflammation typically increases drug absorption rather than decreasing it.
C: Incorrect. Topical administration may vary in effectiveness depending on factors like skin integrity and age.
D: Correct. The occlusive nature of plastic-coated diapers enhances skin absorption in infants.
E, F, G: Choices not provided.
Rationale: Infants wearing plastic-coated diapers are more susceptible to skin absorption due to occlusion by the diaper, leading to increased permeability of the skin and enhanced drug absorption. Plastic-coated diapers create a warm and moist environment that increases skin hydration, facilitating drug penetration. This is important for topical drug absorption in pediatric patients.
Summary:
A: Incorrect. Skin hydration does not solely determine the absorption of water-soluble drugs in pediatric patients.
B: Incorrect. Inflammation typically increases drug absorption rather than decreasing it.
C: Incorrect. Topical administration may vary in effectiveness depending on factors like skin integrity and age.
D: Correct. The occlusive nature of plastic-coated diapers enhances skin absorption in infants.
E, F, G: Choices not provided.