Difficulty: Medium
Average Score: 73%
Simulated
Which of the following has the highest risk of metabolic syndrome?
Correct answer
C
Rationale
The correct answer is C: clozapine (Clozaril). Clozapine has the highest risk of metabolic syndrome among the choices provided. Clozapine is known to have significant side effects including weight gain, dyslipidemia, and insulin resistance, all of which are key components of metabolic syndrome. This drug is associated with the highest risk of metabolic side effects compared to the other antipsychotic medications listed. Haloperidol (A), aripiprazole (B), and lurasidone (D) are generally considered to have a lower risk of causing metabolic syndrome compared to clozapine. In summary, clozapine carries the highest risk of metabolic syndrome due to its effects on weight, lipids, and insulin resistance.