Which difference in pharmacokinetics does the nurse expect in the obese patient as compared with the thin patient with administration of a highly lipid-soluble drug?

The correct answer is D: Drug elimination will be slowed in the obese patient compared to the thin patient with a highly lipid-soluble drug. This is because lipid-soluble drugs tend to accumulate in adipose tissue in obese patients, leading to a larger volume of distribution and a prolonged half-life. This results in a slower elimination of the drug from the body. Choices A, B, and C are incorrect because drug distribution is not necessarily more rapid in obese patients, drug metabolism is not incomplete but rather may be increased due to increased liver size in obesity, and drug absorption is not impaired but may be increased due to increased blood flow in adipose tissue.