When caring for a client with a central venous line, which of the following nursing actions should be implemented in the plan of care for chemotherapy administration? Select all that apply.

E Contact the health care provider about verifying placement if the status is questionable. A Verify patency of the line by the presence of a blood return at regular intervals. B Inspect the insertion site for swelling, erythema, or drainage. C Administer a cytotoxic agent to keep the regimen on schedule even if blood return is not present. D If unable to aspirate blood, reposition the client and encourage the client to cough.