Difficulty: Medium
Average Score: 63%
Simulated
What is the primary mechanism of Ibuprofen├óÔé¼Ôäós therapeutic action?
Correct answer
A
Rationale
Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) that exerts its analgesic and anti-inflammatory effects through reversible inhibition of cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) enzymes. This reduces prostaglandin synthesis, leading to decreased inflammation, pain, and fever. The improvement in pain and swelling confirms inhibition of prostaglandin-mediated processes. Unlike aspirin, ibuprofen├óÔé¼Ôäós COX inhibition is reversible, allowing for shorter duration of platelet effects. Its mechanism underlies its common use in musculoskeletal pain and inflammatory conditions.