Difficulty: Medium
Average Score: 82%
Simulated
What is the main neurotransmitter abnormality in Tourette's?
Correct answer
A
Rationale
The correct answer is A: Dopamine. In Tourette's, there is evidence of dysregulation in the dopamine system, leading to motor and vocal tics. Dopamine plays a key role in motor control and is implicated in the pathophysiology of Tourette's. Serotonin, glutamate, and GABA abnormalities are also observed in Tourette's, but dopamine abnormalities are most strongly associated. Serotonin abnormalities are more linked to OCD and mood disorders often comorbid with Tourette's. Glutamate and GABA abnormalities are involved in other neurological conditions but not the primary neurotransmitter dysfunction in Tourette's.