The therapeutic management of children with ├â┼©-thalassemia major consists primarily of:

The correct answer is D: Blood transfusions and chelation therapy. Children with ╬▓-thalassemia major require regular blood transfusions to manage their anemia. Chelation therapy is essential to remove excess iron from the body due to the iron overload from transfusions. Immunizations (A) are important but not the primary management. Adequate hydration (B) is necessary but not the primary therapy. Oxygen therapy (C) may be needed in some cases but is not the primary management for thalassemia major.