The nurse understands which of the following clients with depression are appropriate for phenelzine [Nardil]?

The correct answer is B: Clients who have not responded to SSRIs and TCAs. Phenelzine is a monoamine oxidase inhibitor (MAOI) used for treatment-resistant depression. Clients who have not responded to selective serotonin reuptake inhibitors (SSRIs) and tricyclic antidepressants (TCAs) may benefit from phenelzine due to its mechanism of action. MAOIs can be effective when other antidepressants have failed. Choices A, C, and D are incorrect because using phenelzine in clients with new onset signs of schizophrenia, in combination with an SSRI for increased symptoms, and in postpartum depression/lactating clients respectively, are not supported by evidence-based practice.