The nurse is caring for a client newly diagnosed with hypertension and requires medication therapy. Which of the following medications below is considered a first-line treatment for hypertension?

The correct answer is D: Lisinopril. Lisinopril is considered a first-line treatment for hypertension because it is an ACE inhibitor, which is recommended as initial therapy by major guidelines. ACE inhibitors like lisinopril have shown to reduce mortality, prevent target organ damage, and are well tolerated. Carvedilol (A) is a beta-blocker, Clonidine (B) and Doxazosin (C) are not typically used as first-line agents due to side effects and limited efficacy in monotherapy for hypertension.