Difficulty: Medium
Average Score: 72%
Simulated
A patient who received a renal transplant three months ago is readmitted to the acute care unit with signs of graft rejection. During the patientÔÇÖs history taking, the nurse finds out that the patient has been self-administering St. JohnÔÇÖs Wort, an herbal preparation, on a friendÔÇÖs advice. What information is most significant about this finding?
Correct answer
A
Rationale
St. JohnÔÇÖs Wort induces CYP3A4, reducing cyclosporine levels (A), risking transplant rejection. It doesnÔÇÖt affect sodium (B) or reduce corticosteroid needs (C). Depression treatment (D) is secondary to the transplant risk.