Difficulty: Medium
Average Score: 95%
Simulated
A nurse reads in a drug information guide that PO morphine has a high first-pass effect. Which of the following would the nurse expect?
Correct answer
B
Rationale
The correct answer is B: The drug will be more effective when given in a non-enteral route. When a drug has a high first-pass effect, it means a significant portion of the drug is metabolized by the liver before it reaches systemic circulation when taken orally (PO). By choosing a non-enteral route (such as intravenous or intramuscular), the drug can bypass the liver metabolism, leading to higher bioavailability and effectiveness. Therefore, the nurse would expect the drug to be more effective when given through a non-enteral route.
Choice A is incorrect because a high first-pass effect decreases the effectiveness of the drug when given orally. Choices C and D are also incorrect because the first-pass effect mainly affects drug metabolism in the liver, not kidney excretion.
Choice A is incorrect because a high first-pass effect decreases the effectiveness of the drug when given orally. Choices C and D are also incorrect because the first-pass effect mainly affects drug metabolism in the liver, not kidney excretion.