A nurse is teaching a client who has a new prescription for diphenhydramine for allergic rhinitis. The nurse should instruct the client to monitor for which of the following manifestations as an adverse effect of this medication? (Select all that apply.)

Correct Answer: C,D
Rationale:
C: Urinary retention is a common adverse effect of diphenhydramine due to its anticholinergic properties, which can lead to urinary hesitancy and retention.
D: Dry mouth is another common adverse effect of diphenhydramine due to its anticholinergic properties, which reduce saliva production.
A: Nonproductive cough is not a typical adverse effect of diphenhydramine. It is more commonly associated with ACE inhibitors.
B: Drowsiness is a common side effect of diphenhydramine but is not listed as an adverse effect to monitor for in this scenario.
E: Skin rash is not a typical adverse effect of diphenhydramine. It is more commonly seen with allergic reactions to the drug itself.