A nurse is providing teaching to a client who has a new prescription for rifampin. Which of the following statements should the nurse include in the teaching?

The correct answer is D: Your urine will turn orange while you are taking this medication. Rifampin is known to cause orange discoloration of bodily fluids, including urine, sweat, and tears. This is a harmless side effect and should be expected. Choice A is incorrect because rifampin can reduce the effectiveness of oral contraceptives. Choice B is incorrect as wearing soft contact lenses can lead to discoloration. Choice C is incorrect as rifampin is usually taken once daily in the morning.