A nurse is monitoring for an infusion reaction for a client who is receiving a dose of IV amphotericin B. Which of the following findings should indicate to the nurse that the client is experiencing an acute infusion reaction?

The correct answer is B: Fever. This is indicative of an acute infusion reaction to IV amphotericin B, a common adverse effect. Fever can be a sign of an immediate inflammatory response to the medication, requiring prompt intervention. Hyperglycemia (choice A) is not typically associated with an acute infusion reaction to amphotericin B. Pedal edema (choice C) and dry cough (choice D) are not specific to infusion reactions and may indicate other conditions. It is important for the nurse to recognize fever as a potential sign of an acute reaction to ensure timely treatment and prevent further complications.