Difficulty: Medium
Average Score: 65%
Simulated
A nurse is educating a client who is prescribed clozapine. Which of the following findings should the nurse identify as consistent with agranulocytosis and instruct the client to monitor?
Correct answer
B
Rationale
The correct answer is B: Sore throat and muscle aches. Agranulocytosis is a serious side effect of clozapine, characterized by a significant decrease in white blood cells, specifically granulocytes. This can lead to a weakened immune system, making the client susceptible to infections. Sore throat and muscle aches are early signs of agranulocytosis and should be monitored closely.
Respiratory depression and a comatose state (Choice A) are more indicative of opioid overdose or respiratory depression due to sedative medications, not agranulocytosis. Increased anxiety and suicidal ideations (Choice C) are concerning for mental health issues but not specific to agranulocytosis. Severe restlessness (Choice D) could be a symptom of akathisia, a common side effect of antipsychotic medications, but not directly related to agranulocytosis.
Respiratory depression and a comatose state (Choice A) are more indicative of opioid overdose or respiratory depression due to sedative medications, not agranulocytosis. Increased anxiety and suicidal ideations (Choice C) are concerning for mental health issues but not specific to agranulocytosis. Severe restlessness (Choice D) could be a symptom of akathisia, a common side effect of antipsychotic medications, but not directly related to agranulocytosis.