A nurse is caring for a client who reports to the clinic for laboratory tests. The client has an acute kidney injury caused by acute tubular necrosis and asks why their glomerular filtration rate keeps decreasing. Which of the following pathophysiological changes occurring in the kidney should the nurse explain as the cause of decrease?

A The glomerular filtration rate decreases because inflammatory cells invade the already damaged kidneys. C The glomerular filtration rate decreases because there is obstruction leading to the filtration system backing up and eventually shutting the kidneys down. B The glomerular filtration rate decreases because there is a reduction of blood flow to the kidneys. D The glomerular filtration rate decreases because there is injury to the renal tubular cells.