A nurse is assessing a client who is receiving heparin therapy for deep-vein thrombosis. Which of the following findings should indicate to the nurse that the therapy is effective?

The correct answer is D: Reduced calf circumference. This indicates the heparin therapy is effective in treating deep-vein thrombosis by reducing swelling and inflammation in the affected limb. The reduction in calf circumference suggests decreased edema, improved blood flow, and resolution of the clot. Platelets in the expected range (Choice A) are not directly related to the effectiveness of heparin therapy for DVT. Decreased INR (Choice B) would actually be concerning as it may indicate inadequate anticoagulation. Presence of pedal pulses bilaterally (Choice C) is important for assessing peripheral perfusion but not specific to monitoring heparin therapy for DVT.