A nurse develops a delayed hypersensitivity reaction after wearing latex gloves. Which pathophysiologic process is involved in this type of hypersensitive reaction?

C Immediate allergic reaction mediated by sensitized mast cells. B Antibodies are formed against antigens on cell surfaces. A T-cells sensitization initiates the macrophage release of cytokines causing a delayed reaction. D Antigen-antibody complexes deposit in tissues activating inflammation.