A client who received a renal transplant three months ago is readmitted to the acute care unit with signs of graft rejection. While taking the clientÔÇÖs history, the nurse determines that the client has been self-administering St. John's Wort, an herbal preparation on the advice of a friend. Which information is most significant about this finding?

E Adding the herb can decrease the need for corticosteroids. C Ingestion of wort can reduce the clientÔÇÖs intake of sodium. A The client probably used this herb to treat depression. B Wort can decrease plasma concentrations of the cyclosporine. D Adding the herb can decrease the need for corticosteroids.