A client is receiving high doses of methotrexate and is experiencing severe bone marrow suppression. The nurse expects which intervention to be ordered with this drug to reduce this problem?

The correct answer is B: Leucovorin rescue. Leucovorin is a form of folic acid that helps protect normal cells from the toxic effects of methotrexate. It is often used in high-dose methotrexate therapy to reduce bone marrow suppression. Filgrastim (choice A) is a medication used to stimulate the production of white blood cells, not to counteract the bone marrow suppression caused by methotrexate. Whole blood transfusion (choice C) is used to treat severe anemia, not specifically related to methotrexate-induced bone marrow suppression. Allopurinol (choice D) is used to prevent or treat high levels of uric acid in the blood, not to reduce bone marrow suppression.