A client has been taking oxycodone for pain. The client has returned three times for refills of the prescription. In addition to slurred speech, which assessment leads the nurse to suspect opioid intoxication?

The correct answer is C: Constricted pupils. Opioid intoxication typically causes miosis, or constricted pupils, due to the effects on the autonomic nervous system. This is a classic sign of opioid use. Slurred speech is also a common symptom of opioid intoxication, but constricted pupils are a more specific assessment finding. Choices A, B, and D are not indicative of opioid intoxication. Lability of mood (A) and hypervigilance (B) are more commonly associated with other conditions such as mood disorders or anxiety. Increased respirations (D) are not typical in opioid intoxication, as opioids tend to depress the respiratory system.