The home health hospice nurse visits a client who is newly prescribed extended-release oxycodone 40 mg orally, scheduled every 12 hours to treat severe chronic cancer pain. Which information is most important to reinforce to the clientÔÇÖs caregiver?

D Request a tapered dose from the health care provider if pain decreases to prevent tolerance A Administer the medication around the clock even if the client denies having pain C Change the dosage and frequency to 20 mg every 6 hours if breakthrough pain occurs B Avoid administering with immediate-release opioids to prevent respiratory depression